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PDF Link: Autoantibodies Associated with Diseases of the CNS

Linked is a lengthy PDF article regarding multiple auto-immune diseases affecting the Central Nervous System.

Several CNS disorders associated with specifi c antibodies to ion channels, receptors, and other synaptic proteins have
been recognised over the past 10 years, and can be often successfully treated with immunotherapies. Antibodies to
components of voltage-gated potassium channel complexes (VGKCs), NMDA receptors (NMDARs), AMPA receptors
(AMPARs), GABA type B receptors (GABABRs), and glycine receptors (GlyRs) can be identifi ed in patients and are
associated with various clinical presentations, such as limbic encephalitis and complex and diff use encephalopathies.
These diseases can be associated with tumours, but they are more often non-paraneoplastic, and antibody assays can
help with diagnosis. The new specialty of immunotherapy-responsive CNS disorders is likely to expand further as
more antibody targets are discovered. Recent fi ndings raise many questions about the classifi cation of these diseases,
the relation between antibodies and specifi c clinical phenotypes, the relative pathological roles of serum and intrathecal
antibodies, the mechanisms of autoantibody generation, and the development of optimum treatment strategies.


The PDF can be found at Google Articles, published by in their August 2011 journal, Volume 10.

Copyright © 2011 The Lancet






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