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Link: A Case of Refractory Hashimoto’s Encephalopathy Demonstrating Improvement with Plasmapheresis (P5.227)

Objective

To describe an unusual case of Hashimoto’s encephalopathy (HE) associated with significant imaging findings that responded to plasmapheresis.

Background

Hashimoto’s thyroiditis was first described by Hakaru Hashimoto in 1912 but it was Lord Brain who first noted the association between thyroiditis and an unusual encephalopathy in 1966 that he called Hashimoto’s encephalopathy. As it appears unlikely that thyroid disease has a direct role in causing this disorder, many prefer the term “steroid-responsive encephalopathy associated with autoimmune thyroiditis” because of the disorder’s responsiveness to corticosteroids. HE can present with multiple neurologic manifestations, and its diagnosis requires the presence of anti-thyroid antibodies and the exclusion of other etiologies. While its progressive form is often well-recognized, patients with a waxing and waning course may provide diagnostic difficulty. Treatment with corticosteroids has been well-documented, but the benefit of immune-related therapies such as plasmapheresis has not been solidified.

 

 

The abstract of this study can be found at http://www.neurology.org/content/82/10_Supplement/P5.227.short. However, you may need to purchase the article or subscribe to the American Academy of Neurology to read the full text of this article.

Copyright © 2014 American Academy of Neurology | by Dr. Sarah Nelson, Dr. Yasir Jassam, and Dr. Lynne Taylor

Published in Neurology April 8th, 2014  vol. 82, no. 10 Supplement P5.227

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