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Link: Nuclear receptors in inflammation control: repression by GR and beyond

Inflammation is a protective response of organisms to pathogens, irritation or injury. Primary inflammatory sensors activate an array of signaling pathways that ultimately converge upon a few transcription factors such as AP1, NFκB and STATs that in turn stimulate expression of inflammatory genes to ultimately eradicate infection and repair the damage. A disturbed balance between activation and inhibition of inflammatory pathways can set the stage for chronic inflammation which is increasingly recognized as a key pathogenic component of autoimmune, metabolic, cardiovascular and neurodegenerative disorders.

The full text of this study can be found at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787948/.

 

Copyright © Mol Cell Endocrinol November 2013 | by Yurii Chinenov, Rebecca Gupte, and Inez Rogatsky

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