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Link: Clinical Features of Infectious and Autoantibody Encephalitis

COMMENTARY. In this study, using the Granerod classification [2], encephalitis was defined as an acute encephalopathy with >-2 of the following: fever >38 °C, seizures or focal neurologic signs, CSF pleocytosis (>5wbc/uL) or elevated CSF neopterin (>30nmol/L), and EEG slowing or abnormal MRI. Confirmed diagnosis had the organism or autoantibody detected in CSF or brain. A probable diagnosis had serological evidence of acute infection or autoantibody, and a possible diagnosis was based on detection of the organism from stool or nasopharynx. The term infection-associated encephalopathy rather than encephalitis was used for encephalitis related to influenza virus or rotavirus. Encephalopathy is defined as an altered or reduced level of consciousness and change in personality or behavior or confusion lasting >24 hours.

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