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Thyroid Antibodies

The most clinically relevant anti-thyroid autoantibodies are anti-thyroid peroxidase antibodies (anti-TPO antibodies), thyrotropin receptor antibodies (TRAbs) and thyroglobulin antibodies. – Wikipedia

  • Link: Cognitive and affective dysfunctions in autoimmune thyroiditis
    Hashimoto’s thyroiditis (HT) is the most frequent cause of hypothyroidism in areas with sufficient iodine intake. While the impact of thyroid function on mood and cognition is well known, only in the recent years, an increasing number of studies report on the association of HT with cognitive and affective disturbances also in the euthyroid state. […]
  • Link: Antithyroid antibody-linked symptoms in borderline personality disorder
    Circulating thyroid autoantibodies are more prevalent in patients with mood disorders than in the general population, but longitudinal clinical data that establish a relationship between thyroid antibody status and the course of any psychiatric syndrome have been lacking. In addition, scant attention has been paid to thyroid hormones and autoimmunity in borderline personality disorder (BPD). […]
  • Link: When Hashimoto’s is misdiagnosed as bipolar disorder
    After a bipolar diagnosis, this patient was prescribed eight different psychotropic medications and received a dozen electroconvulsive treatments. After six months of support for Hashimoto’s, her symptoms resolved and she is now drug-free, with the exception of thyroid hormone medication. Was her bipolar disorder simply misdiagnosed Hashimoto’s?   The full article can be found at http://drknews.com/when-hashimotos-is-misdiagnosed-as-bipolar-disorder/. […]
  • Link: Hashimoto’s encephalopathy: A frequently missed diagnosis
    Hashimoto’s encephalopathy is described as a syndrome of encephalopathy and high serum antithyroid antibodies that is responsive to glucocorticoid therapy. We report a patient with overt hypothyroidism who presented with stroke-like episodes and a status epilepticus which responded dramatically to intraveous methylprednisolone given for a severe bronchospasm following aspiration. The high antithyroid antibody titers and […]
  • Link: The use of plasma exchange in Hashimoto's encephalopathy: A case report and review of the literature.
    Hashimoto’s Encephalopathy (HE) is a very rare condition characterized by psychosis, seizures, cognitive fluctuations, and myoclonus. In a few published cases, plasma exchange has been used due to the theoretical removal of antithyroid peroxidase antibodies (anti-TPO), one of the postulated causes of the condition.   The abstract can be found at unboundmedicine.com; however, the full […]
  • Link: Pediatric Hashimoto's encephalopathy with peripheral nervous system involvement
    Hashimoto encephalopathy is a syndrome of encephalopathy associated with elevated concentration of circulating serum anti-thyroid antibodies usually responsive to steroid therapy. We report a 13-year-old girl with Hashimoto encephalopa- thy and peripheral nervous system involvement. The child had experienced high-grade pyrexia, global headache and sleeplessness. After admission she had an ileus with a distended urinary […]
  • Link: Catatonia: A Duel of Hashimoto’s Encephalopathy and Anti NMDA Receptor Encephalitis (P5.166)
    OBJECTIVE To present a unique case of diagnostic conundrum in a catatonic patient positive for both anti NMDA receptor and anti TPO antibodies with a normal 24 hour EEG, brain MRI and CSF.BACKGROUND:Catatonia, although typically associated with schizophrenia and other affective disorders, can be an uncommon presenting feature of two rare neurologic disorders: Hashimoto’s encephalopathy […]
  • Link: Hashimoto's Encephalopathy - A Brief Review
    Hashimoto’s encephalopathy (HE) is a syndrome of altered mental status, hallucinations, delusional thinking, and often, epileptic seizures. It is diagnosed by the clinical syndrome, the presence of elevated titers of antithyroid antibodies, the lack of another diagnosis based on clinical evaluation, and the response to corticosteroid and other immunosuppressant treatment. This review discusses the symptoms, […]
  • Link: Steroid-Responsive Encephalopathy Associated with Autoimmune Thyroiditis Presenting with Diffusion MR Imaging Changes

    Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) presents with focal or diffuse nonenhancing MR imaging abnormalities in 50% of patients with SREAT during subacute exacerbation.

  • Link: Hashimoto's Encephalopathy Complicated by Cerebellar Ataxia: A Case Report

    To present a case of Hashimoto’s Encephalopathy (HE) with long-term neurological sequelae.BACKGROUND: Hashimoto’s Encephalopathy, also known as steroid responsive encephalopathy secondary to autoimmune thyroiditis (SREAT), is a rare condition that typically affects middle aged females with known anti-TPO antibodies and a history of Hashimoto’s thyroiditis. The diagnosis is often overlooked because there is no diagnostic biomarker, and patients can present with several non-specific neurological symptoms that are often incorrectly attributed to other disease processes. Neurological outcomes are rarely reported. It is important to recognize and distinguish HE from other encephalopathies as it is a distinct, treatable entity, which is almost always responsive to steroid therapy.

  • Link: A follow-up 18F-FDG brain PET study in a case of Hashimoto's encephalopathy causing drug-resistant status epilepticus treated with plasmapheresis

    Hashimoto’s encephalopathy (HE) is a rare neuropsychiatric syndrome associated with antithyroid antibodies. It may have an acute onset (episodes of cerebral ischemia, seizure, and psychosis) or it may present as an indolent form (depression, cognitive decline, myoclonus, tremors, and fluctuations in level of consciousness). We here describe a case of encephalopathy presenting as non-convulsive status epilepticus associated with Hashimoto’s thyroiditis (HT), unresponsive to corticosteroid therapy, with improvement after plasma exchange treatment.

  • Link: Hashimoto's Thyroiditis in Patients With Normal Thyroid-stimulating Hormone Levels
    This study discusses the impact that Hashimoto’s Thyroiditis (also known as Hashimoto’s Disease) on patient quality of life. It also touches on the topic of eurthyroid patients continuing to experience a range of symptoms even while remaining within reference ranges on Thyroid Function Tests. The study can be found at http://www.medscape.com/viewarticle/760417 The full text of […]
  • Link: Steroid-responsive Encephalopathy in Autoimmune Thyroiditis: Clinical Spectrum and MRI Observations in Three Cases
    This study looks at three cases of Hashimoto’s Encephalopathy, discussing MRI and EEG observations in each case. To read the full text, proceed to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077662/. The full text of this article is found at PMC and was published in 2011. Copyright © Annals of Indian Academy of Neurology   Is there a tag missing? Suggest […]
  • Link: Hashimoto’s Encephalopathy Cases: Chinese Experience
    This study discusses Hashimoto’s Encephalopathy and it’s presentation of multiple neurologic symptoms and high anti-body titer. It specifically focuses on the Chinese population but may be of some interest for the purpose of personal research.   The full text of this article is found at BMC Neurology. Copyright © 2012 Tang et al.; licensee BioMed […]

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