Limbic Encephalitis

Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain. Limbic encephalitis is caused by autoimmunity: an abnormal state where the body produces antibodies against itself. Some cases are associated with cancer and some are not. – Wikipedia

• Link: Autoimmune Channelopathies of the Nervous System
  Ion channels are complex transmembrane proteins that orchestrate the electrical signals necessary for normal function of excitable tissues, including the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. Progress in molecular biology has allowed cloning and expression of genes that encode channel proteins, while comparable advances in biophysics, including patch-clamp electrophysiology and […]
• Link: Autoantibodies to neuronal surface antigens in thyroid antibody-positive and -negative limbic encephalitis
  Background : Thyroid antibodies (Thy-Abs) are frequently detected in various autoimmune disorders in coexistence with other systemic autoantibodies. In association with an encephalopathy, they are often taken as evidence of Hashimoto’s encephalitis (HE). However, the presence of Thy-Abs in a cohort of limbic encephalitis (LE) patients and their association with anti-neuronal autoimmunity has not been […]
• Dr. Josep Dallmau
  Josep Dalmau Unknown affiliation Verified email at uphs.upenn.edu Dr. Dalmau’s current published works can be found at https://scholar.google.co.uk/citations?user=Sr8izWkAAAAJ&hl=en&oi=sra. This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, […]
• Dr. Joel Oger
  Joel Oger Docteur en mèdecine Professor emeritus University of British Columbia… · Department of Medicine A list of citations by Dr. Joel Oger can be found here at his http://www.researchgate.net profile.   This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No […]
• Link: Autoimmune Limbic Encephalitis With GAD Antibodies
  The neurologic presentation of limbic encephalitis is variable and when it occurs due to a rare cause the diagnosis may be problematic. We present a case of autoimmune limbic encephalitis due to glutamic acid decarboxylase antibody and consider the magnetic resonance imaging and antineural antibody screening aspects in the diagnosis of this entity. This study […]
• Link: Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition
  The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely biomarkers for the presence of the tumour. Thus it was thought that antibodies rarely, if ever, cause CNS disease. Over the past 10 years, identification of autoimmune forms […]
• Link: Systemic and neurologic autoimmune disorders associated with seizures or epilepsy.
  

  Autoimmune limbic encephalitis (ALE) is a severe, but treatable, neuropsychiatric disorder that is difficult to diagnose clinically. With the goal of improving diagnosis of this disorder, we retrospectively evaluated the cerebral FDG PET pattern in a group of patients with ALE.

• Link: Systemic and neurologic autoimmune disorders associated with seizures or epilepsy.
  

  In this article, we review the incidence and significance of seizures in well-established autoimmune disorders, including multiple sclerosis (MS), diabetes mellitus, celiac disease, thyroid disease, and systemic lupus erythematosus (SLE).

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