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HE-2014

Link: The use of plasma exchange in Hashimoto’s encephalopathy: A case report and review of the literature.

Hashimoto’s Encephalopathy (HE) is a very rare condition characterized by psychosis, seizures, cognitive fluctuations, and myoclonus. In a few published cases, plasma exchange has been used due to the theoretical removal of antithyroid peroxidase antibodies (anti-TPO), one of the postulated causes of the condition.

 

The abstract can be found at unboundmedicine.com; however, the full text seems to only be available by purchase from the publisher. The full text can be published at http://onlinelibrary.wiley.com/doi/10.1002/jca.21353/full.

 

Copyright © Journal of Clinical Apheresis 2014

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Pediatric Hashimoto’s encephalopathy with peripheral nervous system involvement

Hashimoto encephalopathy is a syndrome of encephalopathy associated with elevated concentration of circulating serum
anti-thyroid antibodies usually responsive to steroid therapy. We report a 13-year-old girl with Hashimoto encephalopa-
thy and peripheral nervous system involvement. The child had experienced high-grade pyrexia, global headache and
sleeplessness. After admission she had an ileus with a distended urinary bladder, hallucinations and cognitive impair
ment. She had reduced deep tendon reflexes and distal sensory deficiency.
The article may be “rented” or purchased from ReadCube. We were unable to find a full text copy of this study.
Copyright © 2014 The Authors, Pediatrics International, Japan Pediatric Society

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Catatonia: A Duel of Hashimoto’s Encephalopathy and Anti NMDA Receptor Encephalitis (P5.166)

OBJECTIVE

To present a unique case of diagnostic conundrum in a catatonic patient positive for both anti NMDA receptor and anti TPO antibodies with a normal 24 hour EEG, brain MRI and CSF.BACKGROUND:Catatonia, although typically associated with schizophrenia and other affective disorders, can be an uncommon presenting feature of two rare neurologic disorders: Hashimoto’s encephalopathy and anti NMDA receptor encephalitis. Here we describe a case of anti NMDA receptor encephalitis in a catatonic patient positive for both anti TPO and anti NMDA receptor antibodies with a negative 24 hour EEG, normal brain MRI and CSF

The abstract can be found at http://www.neurology.org/content/82/10_Supplement/P5.166.short. The full study may be obtained from the American Academy of Neurlogy; however, we could not find the article elsewhere online at this time.

 

Copyright © 2014 American Academy of Neurology

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Severe complication of catatonia in a young patient with Hashimoto’s encephalopathy comorbid with Cornelia de Lange syndrome

Dear Editor,

Cornelia de Lange syndrome (CdLs) is a rare genetic disease diagnosed as a cluster of symptoms; however, there are only a few reports mentioning the immunologic problems in patients with CdLs. Hashimoto’s encephalopathy (HE) is an autoimmune encephalitis, which manifests as neurocognitive impairment and elevated antithyroid antibody (ATA) titers. Childhood HE manifests especially as more neuropsychiatric symptoms. However, there are no reports discussing the most severe neuropsychiatric complication, that is, catatonia, in HE. We herein report the first case of a severe complication of catatonia in a patient with HE comorbid with CdLs.

The full text of this “letter to the editor” published in Kaohsiung Journal of Medical Sciences can be found at http://www.kjms-online.com/article/S1607-551X(14)00142-9/fulltext.

Copyright © 2014 Published by Elsevier Inc. | by Yen-Wen Chen, Pi-Lien Hung, Ching-Kuan Wu, and Ping-Tao Tseng

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Hashimoto’s Encephalopathy – A Brief Review

Hashimoto’s encephalopathy (HE) is a syndrome of altered mental status, hallucinations, delusional thinking, and often, epileptic seizures. It is diagnosed by the clinical syndrome, the presence of elevated titers of antithyroid antibodies, the lack of another diagnosis based on clinical evaluation, and the response to corticosteroid and other immunosuppressant treatment. This review discusses the symptoms, pathophysiology, and treatment of HE. The disorder is important to recognize because aggressive treatment may bring about a favorable clinical outcome. The disorder has a relatively benign prognosis, compared with many of the entities for which it can be mistaken.

The abstract can be found at http://link.springer.com/article/10.1007/s11910-014-0476-2#page-2. The full article can be purchased or “rented” from Springer Link.

 

Copyright ©  July 2014 | by Howard S. Kirshner

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Hashimoto’s encephalopathy mimicking presenile dementia

Abstract

Hashimoto’s encephalopathy (HE), which carries kaleidoscopic clinical presentations, is easily misdiagnosed in clinical practice. Early diagnosis and prompt initiation of steroid therapy are associated with good prognosis. We describe a 50-year-old female patient who had subclinical hypothyroidism and who presented herself with gradual cognitive impairment, accompanied with auditory hallucination and delusion. Increased anti-thyroid antibodies titers were found in her serum and cerebrospinal fluid. The HE diagnosis was confirmed using the laboratory test for anti-thyroid antibodies along with the patient’s clinical presentation. We treated her with steroid pulse therapy, and the results were favorable. We highlight this case to call for early diagnosis and prompt intervention of HE in clinical practice.

The full text can be purchased from Science Direct. This study was published in General Hospital Psychiatry.

 

Copyright © 2014 Elsevier Inc. | General Hospital Psychiatry Volume 36, May/June 2014, Page 360

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Anti-NMDAR encephalitis misdiagnosed as Hashimoto’s encephalopathy

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a well-defined autoimmune disorder. Hashimoto’s encephalopathy (HE) is a still controversial entity, lacking definite diagnostic criteria.

This study discusses a paediatric case of Autoimmune Encephalopathy with presentation similar to Hashimoto’s Encephalitis. The abstract only can be found at http://www.sciencedirect.com/science/article/pii/S1090379813001256. This article is only available by subscription or purchase.

 

Copyright © 2013 European Paediatric Neurology Society. | Published by Elsevier Ltd.

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: A Case of Refractory Hashimoto’s Encephalopathy Demonstrating Improvement with Plasmapheresis (P5.227)

Objective

To describe an unusual case of Hashimoto’s encephalopathy (HE) associated with significant imaging findings that responded to plasmapheresis.

Background

Hashimoto’s thyroiditis was first described by Hakaru Hashimoto in 1912 but it was Lord Brain who first noted the association between thyroiditis and an unusual encephalopathy in 1966 that he called Hashimoto’s encephalopathy. As it appears unlikely that thyroid disease has a direct role in causing this disorder, many prefer the term “steroid-responsive encephalopathy associated with autoimmune thyroiditis” because of the disorder’s responsiveness to corticosteroids. HE can present with multiple neurologic manifestations, and its diagnosis requires the presence of anti-thyroid antibodies and the exclusion of other etiologies. While its progressive form is often well-recognized, patients with a waxing and waning course may provide diagnostic difficulty. Treatment with corticosteroids has been well-documented, but the benefit of immune-related therapies such as plasmapheresis has not been solidified.

 

 

The abstract of this study can be found at http://www.neurology.org/content/82/10_Supplement/P5.227.short. However, you may need to purchase the article or subscribe to the American Academy of Neurology to read the full text of this article.

Copyright © 2014 American Academy of Neurology | by Dr. Sarah Nelson, Dr. Yasir Jassam, and Dr. Lynne Taylor

Published in Neurology April 8th, 2014  vol. 82, no. 10 Supplement P5.227

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Hashimoto’s Encephalopathy Complicated by Cerebellar Ataxia: A Case Report

OBJECTIVE

To present a case of Hashimoto’s Encephalopathy (HE) with long-term neurological sequelae.

BACKGROUND:

Hashimoto’s Encephalopathy, also known as steroid responsive encephalopathy secondary to autoimmune thyroiditis (SREAT), is a rare condition that typically affects middle aged females with known anti-TPO antibodies and a history of Hashimoto’s thyroiditis. The diagnosis is often overlooked because there is no diagnostic biomarker, and patients can present with several non-specific neurological symptoms that are often incorrectly attributed to other disease processes. Neurological outcomes are rarely reported. It is important to recognize and distinguish HE from other encephalopathies as it is a distinct, treatable entity, which is almost always responsive to steroid therapy.

The study can be found at http://www.neurology.org/content/82/10_Supplement/P6.023.short. A membership may be needed to read the full text.

Copyright © 2014 American Academy of Neurology | by Dr. Michael Hossack and Dr. Perry Richardson

 

 

 

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: A follow-up 18F-FDG brain PET study in a case of Hashimoto’s encephalopathy causing drug-resistant status epilepticus treated with plasmapheresis

Hashimoto’s encephalopathy (HE) is a rare neuropsychiatric syndrome associated with antithyroid antibodies. It may have an acute onset (episodes of cerebral ischemia, seizure, and psychosis) or it may present as an indolent form (depression, cognitive decline, myoclonus, tremors, and fluctuations in level of consciousness). We here describe a case of encephalopathy presenting as non-convulsive status epilepticus associated with Hashimoto’s thyroiditis (HT), unresponsive to corticosteroid therapy, with improvement after plasma exchange treatment.

The article appears in the Journal of Neurology and the text can be found at http://link.springer.com/article/10.1007/s00415-013-7228-0#page-1. However, you may have to purchase the article or log into the site to read the full text.

 

Copyright © Springer-Verlag Heildelberg 2014 | Journal of Neurology | April 2014, Volume 261, Issue 4, pp 663-667

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.