Post Archives

Visitor Survey

Visitor Survey

CNS

Link PDF: Autoantibodies associated with diseases of the CNS: new developments and future challenges

Several CNS disorders associated with specifi c antibodies to ion channels, receptors, and other synaptic proteins have been recognised over the past 10 years, and can be often successfully treated with immunotherapies. Antibodies to components of voltage-gated potassium channel complexes (VGKCs), NMDA receptors (NMDARs), AMPA receptors (AMPARs), GABA type B receptors (GABABRs), and glycine receptors (GlyRs) can be identifi ed in patients and are associated with various clinical presentations, such as limbic encephalitis and complex and diff use encephalopathies. These diseases can be associated with tumours, but they are more often non-paraneoplastic, and antibody assays can help with diagnosis. The new specialty of immunotherapy-responsive CNS disorders is likely to expand further as more antibody targets are discovered. Recent fi ndings raise many questions about the classifi cation of these diseases, the relation between antibodies and specifi c clinical phenotypes, the relative pathological roles of serum and intrathecal antibodies, the mechanisms of autoantibody generation, and the development of optimum treatment strategies.

This article by Angela Vincent, Christian Bien, Sarosh Irani, and Patrick Waters talks about conditions of the CNS caused by autoantibodies. The full paper can be found at ResearchGate.net. This was posted to thread https://www.facebook.com/groups/251477975360/permalink/10154711712105361/ on 27th October, 2014 by G.D.

Copyright © The Lancet 2011 | Authors Angela Vincent, Christian Bien, Sarosh Irani, and Patric Waters

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Role of CXCL10 in central nervous system inflammation

The central nervous system (CNS) is a highly complex tissue that is vital for a large number of life-dependent processes. The neurons of the CNS are post-mitotic and cannot be easily replaced or repaired if lost or damaged. The hallmark of neuroinflammation is an influx of leukocytes through the blood–brain barrier or blood–cerebrospinal fluid barrier.

The full article can be downloaded from DovePress.com.

 

Copyright © February 2014 | by Daniela Michlmayr, Clive S McKimmie

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition

The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely biomarkers for the presence of the tumour. Thus it was thought that antibodies rarely, if ever, cause CNS disease. Over the past 10 years, identification of autoimmune forms of encephalitis with antibodies against neuronal surface antigens, particularly the voltage gated potassium channel complex proteins or the glutamate N-methyl-D-aspartate receptor, have shown that CNS disorders, often without associated tumours, can be antibody mediated and benefit from immunomodulatory therapies. The clinical spectrum of these diseases is not yet fully explored, there may be others yet to be discovered and some types of more common disorders (eg, epilepsy or psychosis) may prove to have an autoimmune basis. Here, the known conditions associated with neuronal surface antibodies are briefly reviewed, some general aspects of these syndromes are considered and guidelines that could help in the recognition of further disorders are suggested.

The full article can be read here – https://www.scienceopen.com/document_file/3c3c5aae-83d2-454d-8f94-d575da463f5a/PubMedCentral/3c3c5aae-83d2-454d-8f94-d575da463f5a.pdf.

 

Copyright © BMJ Publishing 2011 | by Luigi Zuliani,Francesc Graus, Bruno Giometto, Christian Bien, and Angela Vincent

 

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Autoimmune Encephalitis © Touch MEdical MEdia 2013 Autoimmune Encephalitis—Antibody Targets and Their Potential Pathogenicity in Immunotherapy-responsive Syndromes

This study discusses the role of antibodies which attack the brain’s neurons, thus causing amnesia, confusion, and seizures. It suggests that Autoimmune Encephalitis should be included in the differential diagnosis for conditions that include these symptoms.

The article can be found at https://www.academia.edu/5228749/Autoimmune_Encephalitis_Touch_MEdical_MEdia_2013_Autoimmune_Encephalitis-Antibody_Targets_and_Their_Potential_Pathogenicity_in_Immunotherapy-responsive_Syndromes.

This article is found at Academia.org. Copyright © 2013

Is there a tag missing? Suggest one below.

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.