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Link: Hashimoto’s encephalopathy: Report of three cases

Both severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is known as Hashimoto’s encephalopathy. Although most patients are found to have Hashimoto’s thyroiditis, less frequently they have Graves’ disease. Clinical manifestations include epilepsy, disturbance of consciousness, cognitive impairment, memory loss, myoclonus, hallucinations, stroke-like episodes, tremor, involuntary movements, language impairment, and gait impairment. Hashimoto’s encephalopathy is a relatively rare disease. As a good response can be obtained with corticosteroid therapy, early diagnosis and treatment is very beneficial for patients. Here we report three patients with Hashimoto’s encephalopathy with typical manifestations of hallucinations that were associated with hypothyroidism, hyperthyroidism, and euthyroid status, respectively. They all showed a dramatic response to methylprednisolone pulse therapy.

 

The full text can be found at http://www.jfma-online.com/article/S0929-6646(12)00064-2/fulltext.

Copyright © 2011 – 2015 Elsevier Inc. | Authors Jan-Shun Chang, Tien-Chun Chang

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Pediatric Hashimoto’s encephalopathy with peripheral nervous system involvement

Hashimoto encephalopathy is a syndrome of encephalopathy associated with elevated concentration of circulating serum
anti-thyroid antibodies usually responsive to steroid therapy. We report a 13-year-old girl with Hashimoto encephalopa-
thy and peripheral nervous system involvement. The child had experienced high-grade pyrexia, global headache and
sleeplessness. After admission she had an ileus with a distended urinary bladder, hallucinations and cognitive impair
ment. She had reduced deep tendon reflexes and distal sensory deficiency.
The article may be “rented” or purchased from ReadCube. We were unable to find a full text copy of this study.
Copyright © 2014 The Authors, Pediatrics International, Japan Pediatric Society

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Severe complication of catatonia in a young patient with Hashimoto’s encephalopathy comorbid with Cornelia de Lange syndrome

Dear Editor,

Cornelia de Lange syndrome (CdLs) is a rare genetic disease diagnosed as a cluster of symptoms; however, there are only a few reports mentioning the immunologic problems in patients with CdLs. Hashimoto’s encephalopathy (HE) is an autoimmune encephalitis, which manifests as neurocognitive impairment and elevated antithyroid antibody (ATA) titers. Childhood HE manifests especially as more neuropsychiatric symptoms. However, there are no reports discussing the most severe neuropsychiatric complication, that is, catatonia, in HE. We herein report the first case of a severe complication of catatonia in a patient with HE comorbid with CdLs.

The full text of this “letter to the editor” published in Kaohsiung Journal of Medical Sciences can be found at http://www.kjms-online.com/article/S1607-551X(14)00142-9/fulltext.

Copyright © 2014 Published by Elsevier Inc. | by Yen-Wen Chen, Pi-Lien Hung, Ching-Kuan Wu, and Ping-Tao Tseng

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Hashimoto’s Encephalopathy – A Brief Review

Hashimoto’s encephalopathy (HE) is a syndrome of altered mental status, hallucinations, delusional thinking, and often, epileptic seizures. It is diagnosed by the clinical syndrome, the presence of elevated titers of antithyroid antibodies, the lack of another diagnosis based on clinical evaluation, and the response to corticosteroid and other immunosuppressant treatment. This review discusses the symptoms, pathophysiology, and treatment of HE. The disorder is important to recognize because aggressive treatment may bring about a favorable clinical outcome. The disorder has a relatively benign prognosis, compared with many of the entities for which it can be mistaken.

The abstract can be found at http://link.springer.com/article/10.1007/s11910-014-0476-2#page-2. The full article can be purchased or “rented” from Springer Link.

 

Copyright ©  July 2014 | by Howard S. Kirshner

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Video: Autoimmune Encephalitis: Patient Perspective

This video has been posted by Autoimmune Encephalitis Alliance to their YouTube.com channel. This video features Susanna Cahalan reading excerpts from her book, Brain on Fire.

Shared by G.D. in this post on 23rd October, 2014.

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.