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IL-17

Link: Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis

Optic neuritis is a common inflammatory manifestation of multiple sclerosis (MS). In experimental autoimmune encephalomyelitis (EAE), the optic nerve is affected as well. Here, we investigated whether autoimmune inflammation in the optic nerve is distinct from inflammation in other parts of the central nervous system (CNS).

 

We were unable to find the full text online for free. However, the full text can purchased from Elsevier.

 

Copyright © August 2014 Elsevier | by Benjamin Kniera, Veit Rothhammera, Sylvia Heinka, Oliver Pukb, Jochen Grawb, Bernhard Hemmera, Thomas Korna

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Kadmon Corporation Researchers Define Importance of ROCK2 Signaling Pathway in Human Autoimmune Response

NEW YORK, NY — (Marketwired) — 11/10/14 — Kadmon Corporation, LLC, today announced the publication of data showing that ROCK2 (Rho-associated coiled-coiled kinase 2) plays a critical role in regulating immune response in humans, representing a new target for the treatment of autoimmune diseases. The publication appears online this week in the Early Edition of the Proceedings of the National Academy of Sciences (PNAS).

The full article can be found at bioportfolio.com.

 

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Th17 Response and Inflammatory Autoimmune Diseases

The proinflammatory activity of T helper 17 (Th17) cells can be beneficial to the host during infection. However, uncontrolled or inappropriate Th17 activation has been linked to several autoimmune and autoinflammatory pathologies. Indeed, preclinical and clinical data show that Th17 cells are associated with several autoimmune diseases such as arthritis, multiple sclerosis, psoriasis, and lupus. Furthermore, targeting the interleukin-17 (IL-17) pathway has attenuated disease severity in preclinical models of autoimmune diseases. Interestingly, a recent report brings to light a potential role for Th17 cells in the autoinflammatory disorder adult-onset Still’s disease (AOSD). Whether Th17 cells are the cause or are directly involved in AOSD remains to be shown. In this paper, we discuss the biology of Th17 cells, their role in autoimmune disease development, and in AOSD in particular, as well as the growing interest of the pharmaceutical industry in their use as therapeutic targets. – Hindawi International Journal of Inflamatory Diseases

 

The full text of this article is found at Hindawi.com at http://www.hindawi.com/journals/iji/2012/819467/ was published in 2012. Copyrightt © 2011 International Journal of Inflamation.

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.