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Link PDF: Autoantibodies associated with diseases of the CNS: new developments and future challenges

Several CNS disorders associated with specifi c antibodies to ion channels, receptors, and other synaptic proteins have been recognised over the past 10 years, and can be often successfully treated with immunotherapies. Antibodies to components of voltage-gated potassium channel complexes (VGKCs), NMDA receptors (NMDARs), AMPA receptors (AMPARs), GABA type B receptors (GABABRs), and glycine receptors (GlyRs) can be identifi ed in patients and are associated with various clinical presentations, such as limbic encephalitis and complex and diff use encephalopathies. These diseases can be associated with tumours, but they are more often non-paraneoplastic, and antibody assays can help with diagnosis. The new specialty of immunotherapy-responsive CNS disorders is likely to expand further as more antibody targets are discovered. Recent fi ndings raise many questions about the classifi cation of these diseases, the relation between antibodies and specifi c clinical phenotypes, the relative pathological roles of serum and intrathecal antibodies, the mechanisms of autoantibody generation, and the development of optimum treatment strategies.

This article by Angela Vincent, Christian Bien, Sarosh Irani, and Patrick Waters talks about conditions of the CNS caused by autoantibodies. The full paper can be found at ResearchGate.net. This was posted to thread https://www.facebook.com/groups/251477975360/permalink/10154711712105361/ on 27th October, 2014 by G.D.

Copyright © The Lancet 2011 | Authors Angela Vincent, Christian Bien, Sarosh Irani, and Patric Waters

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Autoimmune Encephalitis — New Awareness, Challenging Questions

The field of autoimmune encephalopathies has expanded rapidly in the last few years. It is now well-established that a substantial proportion of encephalitides are associated with autoantibodies directed against the extracellular domains of cell-surface proteins which are critical in the regulation of neuronal excitability. These include LGI1, CASPR2, contactin-2 (VGKC-complex antibodies), and the NMDA, AMPA, and GABABreceptors.

 

The full article can be found at http://www.discoverymedicine.com/Sarosh-R-Irani/2011/05/17/autoimmune-encephalitis-new-awareness-challenging-questions/.

Copyright © Discovery Medicine May 2011 | By Sarosh Irani

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Dr. Sarosh R Irani

University of Oxford, Nuffield Department of Clinical Neurosciences
Verified email at ndcn.ox.ac.uk
The list of published studies and articles by Dr. Sarosh Irani can be found at https://scholar.google.com/citations?user=OD3xZncAAAAJ&hl=en.

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: NMDA receptor antibodies associated with distinct white matter syndromes

Objective: To report the clinical and radiologic findings of children with NMDA receptor (NMDAR) antibodies and white matter disorders.

This was posted by G.D. on 26th November, 2014. The full text can be found at http://nn.neurology.org/content/1/1/e2.full.

 

Copyright ©  April 24, 2014 |by Yael Hacohen, MRCPCH, et al.

Published in Neurol Neuroimmunol Neuroinflamm June 2014 vol. 1 no. 1 e2

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Hashimoto’s Encephalitis by by Dr. Sarosh Irani, John Radcliffe Hospital, Oxford

 Hashimoto’s Encephalopathy (HE) was first described in 1966. It is a rare condition, which is probably of autoimmune origin. Autoimmunity describes disorders in which the immune system mistakenly attacks and destroys the body’s tissues. HE is usually defined by the presence of high levels of thyroid antibodies in the blood.  HE has been reported in all age groups but typically affects females of around 50 years of age. – The Encephalitis Society

To read the full text, proceed to http://www.encephalitis.info/information/types-of-encephalitis/types-of-autoimmune-encephalitis/hashimoto-s-encephalitis/

The full text of this article is found at Encephalitis Society. Copyright  © March 17th 2014 Dr. Sarosh Irani, John Radcliffe Hospital, Oxford

This link was posted by G.D. on 18th November to this thread – https://www.facebook.com/groups/564512313648230/permalink/588191237947004/.

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

PDF Link: Autoantibodies Associated with Diseases of the CNS

Linked is a lengthy PDF article regarding multiple auto-immune diseases affecting the Central Nervous System.

Several CNS disorders associated with specifi c antibodies to ion channels, receptors, and other synaptic proteins have
been recognised over the past 10 years, and can be often successfully treated with immunotherapies. Antibodies to
components of voltage-gated potassium channel complexes (VGKCs), NMDA receptors (NMDARs), AMPA receptors
(AMPARs), GABA type B receptors (GABABRs), and glycine receptors (GlyRs) can be identifi ed in patients and are
associated with various clinical presentations, such as limbic encephalitis and complex and diff use encephalopathies.
These diseases can be associated with tumours, but they are more often non-paraneoplastic, and antibody assays can
help with diagnosis. The new specialty of immunotherapy-responsive CNS disorders is likely to expand further as
more antibody targets are discovered. Recent fi ndings raise many questions about the classifi cation of these diseases,
the relation between antibodies and specifi c clinical phenotypes, the relative pathological roles of serum and intrathecal
antibodies, the mechanisms of autoantibody generation, and the development of optimum treatment strategies.

 

The PDF can be found at Google Articles, published by www.thelancet.com in their August 2011 journal, Volume 10.

Copyright © 2011 The Lancet

 

 

 

 

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Cell-surface central nervous system autoantibodies: Clinical relevance and emerging paradigms

This article discusses the recent finding of pathogenic auto-antibodies which appear to go hand-in-hand with Central Nervous System (CNS) diseases which respond well to immunologic treatment.

To read the full text, proceed to http://onlinelibrary.wiley.com/enhanced/doi/10.1002/ana.24200/

The full text of this article is found at Willey.com and was published in 2014. Copyright © 2014 American Neurological Association

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Antibody-Mediated Epilepsies

This study discusses the presence of antibodies against the neuronal surface proteins which lead to drug-resistent epilepsies. These epilepsies respond to immunologic therapies. Most of the article can be found at this link. Unfortunately, the rest of the article is available to subscribers only.

The article can be found at http://www.medlink.com/cip.asp?UID=mlt002s5&src=Search&ref=40036726.

The article is found at Medlink.com. Copyright © 2011.

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Autoimmune Encephalitis © Touch MEdical MEdia 2013 Autoimmune Encephalitis—Antibody Targets and Their Potential Pathogenicity in Immunotherapy-responsive Syndromes

This study discusses the role of antibodies which attack the brain’s neurons, thus causing amnesia, confusion, and seizures. It suggests that Autoimmune Encephalitis should be included in the differential diagnosis for conditions that include these symptoms.

The article can be found at https://www.academia.edu/5228749/Autoimmune_Encephalitis_Touch_MEdical_MEdia_2013_Autoimmune_Encephalitis-Antibody_Targets_and_Their_Potential_Pathogenicity_in_Immunotherapy-responsive_Syndromes.

This article is found at Academia.org. Copyright © 2013

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.