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Link: Leukocyte infiltration across the blood-spinal cord barrier is modulated by sleep fragmentation in mice with experimental autoimmune encephalitis

We have recently shown that mice with experimental autoimmune encephalitis (EAE) have
increased sleep fragmentation (SF) and reduced sleep efficiency, and that the extent of SF
correlates with the severity of disease. It is not yet clear whether and how sleep promotes
recovery from autoimmune attacks. We hypothesized that SF promotes leukocyte infiltration
across the blood-spinal cord barrier, impairs immune regulation, and thus worsens EAE.

The full BioMed Central study can be found at This will open a PDF document. You must have a PDF reading program to view this document.


Copyright © 17th, October 2014 BioMed Central | by Junyun He, Hung Hsuchou, Yi He, Abba J Kastin, Pramod K Mishra, Jidong Fang, Weihong Pan

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