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Dr. Maria Isabel Leite

A public listing of publications authored by Dr. Maria Isabel Leite.

http://www.pubfacts.com/author/Maria+Isabel+Leite

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition

The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely biomarkers for the presence of the tumour. Thus it was thought that antibodies rarely, if ever, cause CNS disease. Over the past 10 years, identification of autoimmune forms of encephalitis with antibodies against neuronal surface antigens, particularly the voltage gated potassium channel complex proteins or the glutamate N-methyl-D-aspartate receptor, have shown that CNS disorders, often without associated tumours, can be antibody mediated and benefit from immunomodulatory therapies. The clinical spectrum of these diseases is not yet fully explored, there may be others yet to be discovered and some types of more common disorders (eg, epilepsy or psychosis) may prove to have an autoimmune basis. Here, the known conditions associated with neuronal surface antibodies are briefly reviewed, some general aspects of these syndromes are considered and guidelines that could help in the recognition of further disorders are suggested.

The full article can be read here – https://www.scienceopen.com/document_file/3c3c5aae-83d2-454d-8f94-d575da463f5a/PubMedCentral/3c3c5aae-83d2-454d-8f94-d575da463f5a.pdf.

 

Copyright © BMJ Publishing 2011 | by Luigi Zuliani,Francesc Graus, Bruno Giometto, Christian Bien, and Angela Vincent

 

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

PDF Link: Autoantibodies Associated with Diseases of the CNS

Linked is a lengthy PDF article regarding multiple auto-immune diseases affecting the Central Nervous System.

Several CNS disorders associated with specifi c antibodies to ion channels, receptors, and other synaptic proteins have
been recognised over the past 10 years, and can be often successfully treated with immunotherapies. Antibodies to
components of voltage-gated potassium channel complexes (VGKCs), NMDA receptors (NMDARs), AMPA receptors
(AMPARs), GABA type B receptors (GABABRs), and glycine receptors (GlyRs) can be identifi ed in patients and are
associated with various clinical presentations, such as limbic encephalitis and complex and diff use encephalopathies.
These diseases can be associated with tumours, but they are more often non-paraneoplastic, and antibody assays can
help with diagnosis. The new specialty of immunotherapy-responsive CNS disorders is likely to expand further as
more antibody targets are discovered. Recent fi ndings raise many questions about the classifi cation of these diseases,
the relation between antibodies and specifi c clinical phenotypes, the relative pathological roles of serum and intrathecal
antibodies, the mechanisms of autoantibody generation, and the development of optimum treatment strategies.

 

The PDF can be found at Google Articles, published by www.thelancet.com in their August 2011 journal, Volume 10.

Copyright © 2011 The Lancet

 

 

 

 

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Autoimmune Encephalitis © Touch MEdical MEdia 2013 Autoimmune Encephalitis—Antibody Targets and Their Potential Pathogenicity in Immunotherapy-responsive Syndromes

This study discusses the role of antibodies which attack the brain’s neurons, thus causing amnesia, confusion, and seizures. It suggests that Autoimmune Encephalitis should be included in the differential diagnosis for conditions that include these symptoms.

The article can be found at https://www.academia.edu/5228749/Autoimmune_Encephalitis_Touch_MEdical_MEdia_2013_Autoimmune_Encephalitis-Antibody_Targets_and_Their_Potential_Pathogenicity_in_Immunotherapy-responsive_Syndromes.

This article is found at Academia.org. Copyright © 2013

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Encefalopatía de Hashimoto

The article discusses two forms of presentation, “vasculitic” which is remitting/relapsing and “progressive” which is characterized by confussion, psychosis, and potentially coma. The original article, published in Spanish, is located at http://www.imedicinas.com/pfw_files/cma/ArticulosR/Neurologia/2002/10/109100206280632.pdf.

The full text can be translated at https://translate.google.com/.

The full text of this article is found at imedicinas.com and was published in 2002.

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.