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N-methyl D-aspartate receptor antibodies

Link: Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice

Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder that associates with prominent memory and behavioural deficits. Patients’ antibodies react with the N-terminal domain of the GluN1 (previously known as NR1) subunit of NMDAR causing in cultured neurons a selective and reversible internalization of cell-surface receptors. –

 

This was shared by G.D. on 25th November, 2014. To read the full text, proceed to http://brain.oxfordjournals.org/content/early/2014/11/11/brain.awu310.

The full text of this article is found at Oxford University Press and was published in May of 2011. Copyright © 2014 Oxford University Press

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