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Link: High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types

To retrospectively determine the frequency of N-Methyl-D-Aspartate (NMDA) receptor (NMDAR) autoantibodies in patients with different forms of dementia.

This full text discusses the discovery of NMDA antibodies in those with dementias. The text can be found at http://onlinelibrary.wiley.com/doi/10.1002/acn3.120/full.

© 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Evaluating Autoimmune Encephalopathies, Dementias, and Epilepsies

August 2014

A number of disorders of the central nervous system previously considered neurodegenerative and untreatable are now recognized as having a treatable autoimmune cause. Improved recognition is facilitated by an expanding profile of neural-specific autoantibodies and when detected in serum or cerebrospinal fluid, these IgG biomarkers reliably predict an autoimmune cause for neurological dysfunction in patients presenting with rapidly progressive brain disorders. New testing profiles relevant to the evaluation of autoimmune encephalopathy, dementia, and epilepsy are now available at Mayo Clinic.

The video and full text can be found at http://www.mayomedicallaboratories.com/. The original post comes from G.D. on 28th August, 2014.

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Immunologically Mediated Dementias

Although most dementias are due to neurodegenerative or vascular disease, it is important to diagnose immunologically mediated dementias quickly because they can be both rapidly progressive and readily treatable. They usually affect function of limbic and cortical structures, but subcortical involvement can also occur. Because of the variety of symptoms and the rapid course, these dementias present a particular challenge to the clinician and may require evaluation and intervention in the inpatient setting. Diagnostic workup typically reveals evidence of an autoimmune process and, in some cases, cancer. In contrast to the neurodegenerative processes, many of the immunologically mediated dementias respond to immunomodulatory therapy.

The full text can be found at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832614/.

Copyright © Current Neurology and Neuroscience | Authors Rosenbloom, Michael H., Sallie Smith, Gulden Akdal, and Michael D. Geschwind

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.