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non-paraneoplastic

Link: Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition

The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely biomarkers for the presence of the tumour. Thus it was thought that antibodies rarely, if ever, cause CNS disease. Over the past 10 years, identification of autoimmune forms of encephalitis with antibodies against neuronal surface antigens, particularly the voltage gated potassium channel complex proteins or the glutamate N-methyl-D-aspartate receptor, have shown that CNS disorders, often without associated tumours, can be antibody mediated and benefit from immunomodulatory therapies. The clinical spectrum of these diseases is not yet fully explored, there may be others yet to be discovered and some types of more common disorders (eg, epilepsy or psychosis) may prove to have an autoimmune basis. Here, the known conditions associated with neuronal surface antibodies are briefly reviewed, some general aspects of these syndromes are considered and guidelines that could help in the recognition of further disorders are suggested.

The full article can be read here – https://www.scienceopen.com/document_file/3c3c5aae-83d2-454d-8f94-d575da463f5a/PubMedCentral/3c3c5aae-83d2-454d-8f94-d575da463f5a.pdf.

 

Copyright © BMJ Publishing 2011 | by Luigi Zuliani,Francesc Graus, Bruno Giometto, Christian Bien, and Angela Vincent

 

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Autoimmune Encephalopathy

This MedScape article in “seminars in neurology”, written by Eoin P. Flanagan, M.B.B.Ch., Richard J. Caselli, M.D. for the Department of Neurology, Mayo Clinic, Rochester, Minnesota; and Department of Neurology, Mayo Clinic, Scottsdale, Arizona., and discusses non-paraneoplastic encephalopathy. It focuses on the global effects of auto-immune encephalopathy laboratory testing, imaging tools, anti-body testing, ruling out cancerous causes, and ruling out CJD, among other topics.

http://www.medscape.com/viewarticle/743774

The full text of this article is found at MedScape and was published in 2011. © 2011 Thieme Medical Publishers

 

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.