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Parkinson’s Disease

Link: Neurological disorders: a public health approach

This informative document discusses public health concerns regarding a few common neurological conditions including dementia and epilepsy. The full document can be found on their website, www.who.int.

© World Health Organisation

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic Implications

Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and myelin production. Though iron deposition has been observed in the brain with normal aging, increased iron has also been shown in many chronic neurologic disorders including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. In vitro studies have demonstrated that excessive iron can lead to free radical production, which can promote neurotoxicity. However, the link between observed iron deposition and pathologic processes underlying various diseases of the brain is not well understood. It is not known whether excessivein vivo iron directly contributes to tissue damage or is solely an epiphenomenon. In this article we focus on the imaging of brain iron and the underlying physiology and metabolism relating to iron deposition. We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development.

The full study can be found at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1963417/. Posted by G.D. on 24th April 2015.

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Mucuna pruriens in Parkinson’s disease: a double blind clinical and pharmacological study

Background: The seed powder of the leguminous plant, Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine for diseases including parkinsonism. We have assessed the clinical effects and levodopa (L-dopa) pharmacokinetics following two different doses of mucuna preparation and compared them with standard L-dopa/carbidopa (LD/CD).

Posted to thread 23rd April, 2015 by M.M.

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Jay A. Van Gerpen, MD

Dr. Van Gerpen works in collaboration with colleagues at Mayo Clinic in Florida who are investigating the genetics of patients with Parkinson’s disease and other movement disorders. His role as a clinician is to recognize such patients and provide relevant biological samples to collaborators in genetics, neuropathology, basic neuroscience and other related areas.

The full profile for Dr. Van Gerpen can be found at http://www.mayo.edu/research/faculty/van-gerpen-jay-a-m-d/bio-00084969.

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Recommendations for optimal ICD codes to study neurologic conditions – a systematic review

Administrative health data are frequently used for large population-based studies. However, the validity of these data for identifying neurologic conditions is uncertain.

This may rest in the realm of research obscura; however, it may benefit some who dig through their records or come across coding in their search for answers.

The full text can be found at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430709/.

 

Copyright © 2012 by AAN Enterprises, Inc. | by Christine St. Germaine-Smith, MSc, Amy Metcalfe, MSc, Tamara Pringsheim, MD, Jodie Irene Roberts, BSc, Cynthia A. Beck, MD, Brenda R. Hemmelgarn, MD, PhD, Jane McChesney, BSc, Hude Quan, MD, and Nathalie Jette

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.