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VGKC complex

Link: Clinical spectrum of voltage-gated potassium channel autoimmunity

Objective:

To document neurologic, oncologic, and serologic associations of patients in whom voltage-gated potassium channel (VGKC) autoantibodies were detected in the course of serologic evaluation for neuronal, glial, and muscle autoantibodies.

The abstract can be found at http://www.ncbi.nlm.nih.gov/pubmed/18474843.

Copyright © Neurology 2009

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

PDF Link: Autoimmune encephalitis – History & current knowledge

This PDF link will take you to a PDF published by PANDAS Network and has a wealth of information about auto-immune diseases.

 

Introduction
The acute fulminating epidemic form of encephalitis lethargica (von Economo, EL) seems to have
disappeared, since there have been no further reported epidemics after 1916-1927. During that period of
time, both rheumatic fever (RF) and Sydenham chorea (SC) were associated with and later proven to be
provoked by streptococcal infections. The occurrence of RF including SC has become much less frequent in
the industrial world.

The full text can be found in a PDF at http://pandasnetwork.org/wp-content/uploads/2013/07/Autoimmune_encephalitis.pdf

 

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition

The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely biomarkers for the presence of the tumour. Thus it was thought that antibodies rarely, if ever, cause CNS disease. Over the past 10 years, identification of autoimmune forms of encephalitis with antibodies against neuronal surface antigens, particularly the voltage gated potassium channel complex proteins or the glutamate N-methyl-D-aspartate receptor, have shown that CNS disorders, often without associated tumours, can be antibody mediated and benefit from immunomodulatory therapies. The clinical spectrum of these diseases is not yet fully explored, there may be others yet to be discovered and some types of more common disorders (eg, epilepsy or psychosis) may prove to have an autoimmune basis. Here, the known conditions associated with neuronal surface antibodies are briefly reviewed, some general aspects of these syndromes are considered and guidelines that could help in the recognition of further disorders are suggested.

The full article can be read here – https://www.scienceopen.com/document_file/3c3c5aae-83d2-454d-8f94-d575da463f5a/PubMedCentral/3c3c5aae-83d2-454d-8f94-d575da463f5a.pdf.

 

Copyright © BMJ Publishing 2011 | by Luigi Zuliani,Francesc Graus, Bruno Giometto, Christian Bien, and Angela Vincent

 

 

This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.

Link: Autoimmune Encephalitis © Touch MEdical MEdia 2013 Autoimmune Encephalitis—Antibody Targets and Their Potential Pathogenicity in Immunotherapy-responsive Syndromes

This study discusses the role of antibodies which attack the brain’s neurons, thus causing amnesia, confusion, and seizures. It suggests that Autoimmune Encephalitis should be included in the differential diagnosis for conditions that include these symptoms.

The article can be found at https://www.academia.edu/5228749/Autoimmune_Encephalitis_Touch_MEdical_MEdia_2013_Autoimmune_Encephalitis-Antibody_Targets_and_Their_Potential_Pathogenicity_in_Immunotherapy-responsive_Syndromes.

This article is found at Academia.org. Copyright © 2013

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This website is not a substitute for independent professional advice. Nothing contained in this site is intended to be used as medical advice. No articles, personal accounts, or other content are intended to be used to diagnose, treat, cure or prevent any disease, nor should it be used for therapeutic purposes or as a substitute for your own health professionals advice.